After a fire in the 13th century the hospital was moved to the site where now 9 St. Thomas Street stands. The adjacent Church which is now the Chapter House of the Cathedral was once the chapel of the Hospital.

As for famous names, Shakespeare's Bankside is not far away; John Keats and John Gower, the poets lived in the street, as did the great surgeons and physicians, Sir Samuel Wuks, Charles Astor Key, John Flint South and John Hilton. Built before the completion of St. Paul's Cathedral, the Battle of Ramillies and the Act of Union, the House has seen the passage of much of English ecclesiastical, medical and mercantile history. The Borough of Southwark has witnessed much of this history. From across the water it has seen the ravages of the Great Fire of London in 1666 to the Blitz of 1942, played host to the great ships from East Indiamen to H.M.S. Belfast in the Pool of London.